{"product_id":"neprinol-afd","title":"Neprinol AFD","description":"\u003cscript\u003e\/\/ \u003c![CDATA[\n  !function(a){if(!window.a2mb){window.a2mb=!0;var e=a.createElement(\"script\");e.async=!0,e.src=\"\/\/badge.arthurandrew.com\/assets\/scripts\/badge.js\",a.body.append(e)}}(document);\n\/\/ ]]\u003e\u003c\/script\u003e\n\u003cdiv class=\"aam-badge\"\u003e\u003c\/div\u003e\n\u003ch1\u003eNeprinol is a revolutionary blend of systemic enzymes and antioxidants specially formulated to support healthy circulatory and immune function.*\u003c\/h1\u003e\n\u003cscript\u003e\/\/ \u003c![CDATA[\n!function(a){if(!window.a2mb){window.a2mb=!0;var e=a.createElement(\"script\");e.async=!0,e.src=\"\/\/badge.arthurandrew.com\/badge.js\",a.body.append(e)}}(document);\n\/\/ ]]\u003e\u003c\/script\u003e\n\u003cdiv class=\"aam-badge\"\u003e\u003c\/div\u003e\n\u003cp\u003eNeprinol's vegetarian enzyme blend tested to be more than 500% more fibrinolytic than the leading animal-based enzyme formulation.† Neprinol's blend of systemic enzymes are similar to digestive enzymes, but are primarily used throughout the bloodstream rather than the gastrointestinal tract. Neprinol supports healthy levels of Endogenous Blood Particles or EBP’s.* EBP’s can be decayed cells, fibrin, fatty proteins, and other unwanted materials that normally accumulate in the blood.* Systemic enzymes like those in Neprinol support the body’s natural purification of these EBP’s, as well as maintaining healthy liver function and healthy inflammatory levels. Sustaining a healthy level of EBP’s is also beneficial for maintaining optimal immune and circulatory function.* Efficacy is of utmost importance to doctors and patients alike and Neprinol addresses this concern with a proven potency that can be utilized by healthcare professionals. Neprinol’s enzymes are remarkably different from typical animal derived systemic enzymes, which are sometimes derived from pork and cow sources. The enzymes in Neprinol are a combination of vegetarian and selectively potent microbial strains. Although these ingredients are extremely potent, they are well tolerated in the body. Neprinol can be recommended for both clinical use and therapeutic applications.\u003c\/p\u003e\n\u003cp\u003eRecent medical breakthroughs, including clinical research performed on Neprinol, have led to the application of systemic enzymes to support the digestion of debris from the cardiovascular system.* This provides for a reduced level of EBP’s, which can support healthy inflammatory responses and their relation to joint discomfort and stiffness.* Healthy, reduced-EBP blood sustains relatively normal blood clotting factors as well. Enzymes support a healthy immune system and may support the repair damaged tissues, and even more remarkably, they require smaller doses over time to maintain their efficacy.*\u003c\/p\u003e\n\u003cp\u003eSystemic enzyme products have been and continue to be under-utilized dietary aids, despite the fact that their use dates back further than most supplements. As we age, the need for enzymes increases significantly. Enzymes are essential to maintain a strong immune system, healthy joints, good circulation and overall balanced reaction to injury.* All of the enzyme components in Neprinol are derived from all-vegetarian sources, which by nature are biochemically more effective than those produced by the human body.* Supplementing with Neprinol, can replace these lost and valuable enzymes. Combined with proper diet and exercise they may drastically reduce vulnerability to a wide range of health concerns.*\u003c\/p\u003e\n\u003cp\u003e†Based on 3rd party fibrinolytic assay testing.\u003c\/p\u003e\n\u003cdiv class=\"sixteen columns\"\u003e\u003c\/div\u003e\n\u003chr class=\"pagedivider\"\u003e\n\u003cbr\u003e\n\u003ch1\u003e\n\u003ci class=\"fa fa-shield\"\u003e\u003c\/i\u003e Fibrin Defense\u003c\/h1\u003e\n\u003cp\u003eFibrin is a protein formed in the human body responsible for scar tissue and thrombus formation. Neprinol contains a blend of fibrinolytic (fibrin degrading) enzymes that specifically address fibrin levels in the body. Our bodies normally secrete sufficient levels of plasmin, an important enzyme present in the blood that degrades many blood plasma proteins and blood clots. Plasmin, our own natural blood thinner, is responsible for maintaining normal blood solvency by removing unnecessary accumulated protein. The normal process of removing excessive fibrin can be enhanced by introducing fibrinolytic enzymes like those found in Neprinol.\u003c\/p\u003e\n\u003ch2\u003eFibrinogen Over-Production\u003c\/h2\u003e\n\u003cdiv class=\"eight columns alpha\"\u003e\n\u003ch5\u003eHyper-coagulation \u0026amp; Fibrin Defense\u003c\/h5\u003e\n\u003cdiv class=\"circular-fibrin-image\"\u003e\u003cimg src=\"\/\/cdn.shopify.com\/s\/files\/1\/0368\/5697\/files\/fibrin.png?3553\" alt=\"\"\u003e\u003c\/div\u003e\n\u003cp\u003eEnzymes can be thought of as proteins on a mission. And when it comes to improving your health, one of the most potent targets an enzyme can seek and destroy is a fibrous protein called fibrin. Neprinol contains a powerful combination of fibrin-dissolving enzymes like serrapeptase, nattokinase and bromelain, as well as other natural ingredients. That is why it is known as Neprinol AFD – Advanced Fibrin Defense®. But to understand why the body needs help defending itself against fibrin you first need to understand a bit more about the protein itself.\u003c\/p\u003e\n\u003ch5\u003eFibrin\u003c\/h5\u003e\n\u003cp\u003eFibrin is an insoluble protein that plays a major role in the formation of blood clots and scar tissue. During the blood clotting process, the soluble protein fibrinogen converts into insoluble fibrin, which is then laid down inside the damaged blood vessel. The fibrin strands then assemble into a net-like gel that hardens and captures all of the materials necessary to patch the damaged vessel. This is the structural framework of a blood clot. Obviously, fibrin plays a vital role in the healing process; however, when there is fibrin overproduction, it can lead to the formation of dangerous and unnecessary blood clots in the body [1]. One factor that can lead to excessive fibrin is ageing.\u003c\/p\u003e\n\u003cp\u003eAs we age, the concentration of fibrinogen increases in our blood [2]. High levels of fibrinogen increases fibrin production, and as fibrin begins to accumulate in the blood vessels it generally leads to the formation of blood clots [3]. Healthy individuals usually have sufficient levels of plasmin, an enzyme that breaks up fibrin blood clots. Unfortunately plasmin production slows down as we get older so the normal process of removing excess fibrin is reduced. The result of this can be cardiovascular disease, heart attacks, strokes, pulmonary emboli, deep vein thrombosis (DVT) and other related disorders [4-8].\u003c\/p\u003e\n\u003ch5\u003eNeprinol\u003c\/h5\u003e\n\u003cp\u003eResearch has shown that protein-dissolving enzymes like those found in Neprinol can slow the production of fibrin and enhance its removal from the body [1]. Neprinol's blend of enzymes generally tests well above 50,000 FU per gram, which means that 50,000 units of fibrin are broken down by each gram of Neprinol powder. Of the enzymes contained in this formula perhaps the most significant is nattokinase, which has been shown to be four times more powerful than our body's own plasmin at breaking down blood clots [9].\u003c\/p\u003e\n\u003ch5\u003eNattokinase\u003c\/h5\u003e\n\u003cp\u003eNattokinase is an enzyme extracted from natto, a fermented soybean 'cheese' that is popular in Japan [10]. The ability of nattokinase to breakdown fibrin has been tested in more than 12 studies [11], and nattokinase has been shown to be the most potent fibrin-degrading enzyme out of more than 200 foods tested [3].\u003c\/p\u003e\n\u003cp\u003eResearchers have found that nattokinase works much in the same way as plasmin [3], which means thatnattokinase literally dissolves fibrin, whether it is holding together blood clots or is part of scar tissue [12]. However, nattokinase also blocks the activity of plasminogen activator inhibitor 1 (PAI-1), which boosts its fibrin-destroying capabilities even more [9,13].\u003c\/p\u003e\n\u003cp\u003ePlasminogen is made into plasmin, the body's fibrin-dissolving enzyme. However, the conversion process is inactivated by PAI-1. This is why high levels of PAI-1 reduce fibrin breakdown and removal [14]. Nattokinase increases fibrin breakdown by blocking PAI-1 so that more plasmin is produced.\u003c\/p\u003e\n\u003cp\u003eBecause of this nattokinase is not only able to stop dangerous blood clots from developing but also helps dissolve any clots that have already formed. As a result, oral nattokinase supplements are recommended for preventing cardiovascular disease [15]. Nattokinase has also been shown to reduce the risk of deep vein thrombosis (DVT) in high-risk patients in combination with pycnogenol[16].\u003c\/p\u003e\n\u003c\/div\u003e\n​\n\u003cdiv class=\"eight columns omega\"\u003e\n\u003ch5\u003eBromelain\u003c\/h5\u003e\n\u003cp\u003eBromelain is an extract from pineapple that contains a number of fibrin-degrading enzymes [17,18], as well as enzymes that enhance this fibrin-dissolving action [19]. Bromelain was shown to increase the conversion of plasminogen into plasmin [20-22]. It has also been shown to prevent the conversion of fibrinogen to fibrin [17]. However, unlike nattokinase, bromelain is not able to dissolve fibrin clumps that have already formed [17].\u003c\/p\u003e\n\u003cp\u003eBecause a high percentage of ingested bromelain is absorbed intact into the bloodstream, protein- and fibrin-degrading activity in the blood can be increased for hours after taking it [23]. Two large-scale trials in patients with heart problems showed that bromelain could almost completely eliminate thrombosis [24].\u003c\/p\u003e\n\u003ch5\u003eSerrapeptase\u003c\/h5\u003e\n\u003cp\u003eSerrapeptase is another important component of Neprinol's advanced fibrin defense. Serrapeptase is a protein-degrading enzyme isolated from the silk worm [25]. It has significant anti-inflammatory and fibrin-removal activity [26], which makes it ideal for preventing blood clot formation associated with cardiovascular disease.\u003c\/p\u003e\n\u003ch5\u003eOther Diseases Linked to Fibrin\u003c\/h5\u003e\n\u003cp\u003eThe buildup of excess fibrin in the body can cause more health problems than just blood clots. Fibrin has also been linked to a number of chronic and progressive diseases like multiple sclerosis [27,28] and asthma [29]. As a result, Neprinol's fibrin-degrading enzymes could prove to be a good treatment option [1,30].\u003c\/p\u003e\n\u003cp\u003eBreaking down fibrin using enzymes may also help a number of conditions that are difficult to treat, such as Peyronie’s disease, Dupuytren’s contracture and Ledderhose’s disease. All of these conditions are characterized by a loss of tissue elasticity, which leads to tissue tearing, then bleeding, clot formation and fibrin deposition. Over time, taking fibrin-degrading enzymes may reduce the amount of scar tissue built up in locations where there has been repeated damage and bleeding [1].\u003c\/p\u003e\n\u003cp\u003eFinally, using enzymes to dissolve fibrin may also play a role in cancer prevention and treatment. Cancer cells often are surrounded by a fibrin coating [31]. Researchers think that the fibrin may provide a type of camouflage for these abnormal cells, allowing them to escape being destroyed by the immune system. It is possible that by removing this fibrin coating, the body could detect cancer cells and destroy them before they are able to gain a foothold in the body.\u003c\/p\u003e\n\u003ch5\u003eAdvanced Fibrin Defense\u003c\/h5\u003e\n\u003cp\u003eAs you can see, excess fibrin can wreak havoc on our bodies, especially as we get older and our natural production of enzymes decreases. However, Neprinol provides a combination of superior fibrin-active enzymes designed to keep fibrin levels in check. Neprinol is an excellent choice for anyone suffering from, or hoping to prevent, the harmful effects of excess fibrin.\u003c\/p\u003e\n\u003c\/div\u003e\n\u003cdiv class=\"sixteen columns\"\u003e\u003c\/div\u003e\n\u003chr class=\"pagedivider\"\u003e\n\u003cbr\u003e\n\u003ch1\u003e\n\u003ci class=\"fa fa-user-md\"\u003e\u003c\/i\u003e Suggested Use\u003c\/h1\u003e\n\u003cp\u003e\u003cstrong\u003eDirections:\u003c\/strong\u003e Take 1 to 4 capsules with 8 oz of water between meals or as directed by your healthcare practitioner. For therapeutic results, take 3 or 4 capsules three times daily.\u003c\/p\u003e\n\u003cp\u003e\u003ci class=\"fa fa-exclamation-triangle\"\u003e\u003c\/i\u003e \u003cstrong\u003eWarning:\u003c\/strong\u003e Do not take Neprinol without the consent of your physician if you are taking anti-coagulants or if you are pregnant or nursing.\u003c\/p\u003e\n\u003ch5\u003eIs Neprinol safe?\u003c\/h5\u003e\n\u003cp\u003eNo serious or adverse side effects have been reported from taking systemic enzymes such as Neprinol. Clinical studies have shown that even extremely large doses of these enzymes are not toxic. If you are taking blood-thinning medication, you should consult with your physician before taking Neprinol.\u003c\/p\u003e\n\u003ch5\u003eWhen is the best time to take Neprinol?\u003c\/h5\u003e\n\u003cp\u003eFor best results, take the product atleast one hour prior to eating and\/or two hours after a meal.\u003c\/p\u003e\n\u003ch5\u003eCan I take Neprinol with other supplements?\u003c\/h5\u003e\n\u003cp\u003eNeprinol can be used safely with other dietary supplements.\u003c\/p\u003e\n\u003ch5\u003eHow long does it take for Neprinol to work?\u003c\/h5\u003e\n\u003cp\u003eAlthough every person is different, some have reported feeling the effects of systemic enzymes in as little as 45 minutes. For therapeutic regimens, the progression may be slow for some and quicker for others. Typically, supplementing the product for a minimum of a month's time is recommended, with the best results occurring anywhere from one to three months thereafter.\u003c\/p\u003e\n\u003cdiv class=\"sixteen columns\"\u003e\u003c\/div\u003e\n\u003chr class=\"pagedivider\"\u003e\n\u003cbr\u003e\n\u003ch1\u003e\n\u003ci class=\"fa fa-leaf\"\u003e\u003c\/i\u003e Supplement Facts\u003c\/h1\u003e\n\u003cdiv class=\"eight columns alpha\"\u003e\n\u003ch5\u003eSerratiopeptidase (Serrapeptase)\u003c\/h5\u003e\n\u003cp\u003eA proteolytic (protein digesting) enzyme with potent fibrinolytic activity that can support healthy fibrin concentrations. It has been clinically shown to thin secretions from the mucus membranes, and also promotes recovery after physical stress, boosting energy levels.\u003c\/p\u003e\n\u003ch5\u003eNattokinase\u003c\/h5\u003e\n\u003cp\u003eA fibrinolytic enzyme that can help to maintain normal blood viscosity and normal cardiovascular health. Like Serrapeptase, Nattokinase can support healthy fibrin concentrations. It has antioxidant effects that may be beneficial to promote normal prostate health, and aids in the elimination of free radicals.\u003c\/p\u003e\n\u003ch5\u003eLipase\u003c\/h5\u003e\n\u003cp\u003eUsed systemically, this enzyme digests fats in the blood and can help to convert fats into energy.\u003c\/p\u003e\n\u003ch5\u003eProtease\u003c\/h5\u003e\n\u003cp\u003eA proteolytic enzyme that, when present in blood serum, plays an important role in blood clotting as well as lysis of clots. Can help support a healthy immune system.\u003c\/p\u003e\n\u003ch5\u003eAmla\u003c\/h5\u003e\n\u003cp\u003eDerived from Indian Gooseberry, Amla contains tannic acid, glucose, cellulose, and calcium. Amla helps maintain normal acid and pH balance, and is traditionally used as a nerve, brain and hair tonic.\u003c\/p\u003e\n\u003ch5\u003ePapain\u003c\/h5\u003e\n\u003cp\u003eA proteolytic enzyme derived from papaya that can promote natural healing of bruises and other tissue injuries.\u003c\/p\u003e\n\u003ch5\u003eBromelain\u003c\/h5\u003e\n\u003cp\u003eA proteolytic enzyme derived from pineapple that acts with the body to promote its normal immune responses. Bromelain can also help to maintain healthy skin conditions.\u003c\/p\u003e\n\u003ch5\u003eRutin\u003c\/h5\u003e\n\u003cp\u003eA flavonoid (plant pigment) that helps to maintain strong capillaries and connective tissue, as well as healthy blood vessels.\u003c\/p\u003e\n\u003ch5\u003eCoenzyme Q\u003csub\u003e10\u003c\/sub\u003e\n\u003c\/h5\u003e\n\u003cp\u003eDecreases the proliferation of free radicals, supporting a healthy immune system. CoQ10 helps promote maintenance of normal cardiovascular function and is a coenzyme that is essential for enzymes to function in the body.\u003c\/p\u003e\n\u003ch5\u003eMagnesium\u003c\/h5\u003e\n\u003cp\u003ePromotes a healthy cardiovascular system, and is essential for cell repair, hormones and a regular heartbeat. Magnesium helps reduce effects of increased stress.\u003c\/p\u003e\n\u003c\/div\u003e\n\u003cdiv class=\"eight columns omega\"\u003e\n\u003cdiv id=\"SupplementFactsMainContainer\"\u003e\n\u003ctable class=\"SupplementFactsContent\"\u003e\n\u003ctbody\u003e\n\u003ctr\u003e\n\u003ctd colspan=\"3\" class=\"padded\"\u003e\u003cspan class=\"SupplementFacts\"\u003eSupplement Facts\u003c\/span\u003e\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd colspan=\"3\" class=\"horizontalRuleThick-bottom\"\u003e\u003cspan class=\"supplement-content\"\u003eServing Size: 1 Capsule\u003c\/span\u003e\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd class=\"horizontalRuleMed\"\u003e\u003c\/td\u003e\n\u003ctd class=\"amtpserv\"\u003eAmount Per Serving\u003c\/td\u003e\n\u003ctd class=\"dailyvalue\"\u003e% Daily Value\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd class=\"ingredients-top\"\u003e\n\u003cspan class=\"Ingredient-Heading\"\u003eMagnesium\u003c\/span\u003e \u003cem\u003e(Citrate)\u003c\/em\u003e\n\u003c\/td\u003e\n\u003ctd class=\"ingredients-top-right\"\u003e8 mg\u003c\/td\u003e\n\u003ctd class=\"ingredients-top-left\"\u003e2%\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003e\u003cspan class=\"Ingredient-Heading\"\u003eProprietary Blend Neprinol AFD™\u003c\/span\u003e\u003c\/td\u003e\n\u003ctd class=\"ingredients-right\"\u003e500 mg\u003c\/td\u003e\n\u003ctd class=\"ingredients-left\"\u003e†\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003e\n\u003cspan class=\"Ingredient-Heading\"\u003eSystemic and Lipolytic Enzyme Blend:\u003c\/span\u003e\u003cbr\u003eSerrapeptase, Nattokinase, Lipase\u003c\/td\u003e\n\u003ctd class=\"ingredients-right\"\u003e15,000 FU\u003c\/td\u003e\n\u003ctd class=\"ingredients-left\"\u003e\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003e\n\u003cspan class=\"Ingredient-Heading\"\u003eNeprinol™ Protease Blend:\u003c\/span\u003e\u003cbr\u003eProtease \u003cem\u003e(derived from Serratia, B. subtilis and A. oryzae)\u003c\/em\u003e\n\u003c\/td\u003e\n\u003ctd class=\"ingredients-right\"\u003e\u003c\/td\u003e\n\u003ctd class=\"ingredients-left\"\u003e\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003e\n\u003cspan class=\"Ingredient-Heading\"\u003eNeprinol™ Enzyme and Cofactor Blend:\u003c\/span\u003e\u003cbr\u003eAmla, Papain, Bromelain, Rutin, Coenzyme Q\u003csub\u003e10\u003c\/sub\u003e\n\u003c\/td\u003e\n\u003ctd class=\"ingredients-right\"\u003e\u003c\/td\u003e\n\u003ctd class=\"ingredients-left\"\u003e\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd colspan=\"3\" class=\"horizontalRuleThick-top\"\u003e† Daily Value Not Established\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003c\/tbody\u003e\n\u003c\/table\u003e\n\u003cp\u003e\u003cstrong\u003eOther Ingredients:\u003c\/strong\u003e Cellulose (Acid Amor™ capsules)\u003c\/p\u003e\n\u003cp\u003eNeprinol™ is free of dairy, gluten, and soy allergens. Contains no artificial colors or preservatives.\u003c\/p\u003e\n\u003cp\u003eKeep out of reach of children. Store in a cool, dry place with lid tightly closed.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eWARNING:\u003c\/strong\u003e Do not take this product without the consent of your physician if you are currently taking anti-coagulants or if you are pregnant or nursing.\u003c\/p\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e\n\u003cdiv class=\"sixteen columns\"\u003e\u003c\/div\u003e\n\u003chr class=\"pagedivider\"\u003e\n\u003cbr\u003e\n\u003ch1\u003e\n\u003ci class=\"fa fa-question-circle\"\u003e\u003c\/i\u003e Frequently Asked Questions\u003c\/h1\u003e\n\u003ch5\u003eWhat is Neprinol?\u003c\/h5\u003e\n\u003cp\u003eNeprinol is a proprietary combination of Serrapeptase, Nattokinase, Protease, Lipase, Bromelain, Papain, Rutin, Amla and other proteolytic enzymes that are specially formulated to assist your body's defense of the damaging effects of fibrin. Neprinol has been used to strengthen the immune and circulatory systems, maintain a healthy inflammatory response and to support the body's natural recovery process.*\u003c\/p\u003e\n\u003ch5\u003eWhat are Enzymes?\u003c\/h5\u003e\n\u003cp\u003eEnzymes are proteins (or protein-based molecules) that act as catalysts in biochemical reactions. Every enzyme has a specific reactant known as a substrate, which can be thought of like a lock and a key. Only a specific enzyme (or key) will react (or unlock) its substrate. This is the reason why enzymes are unable to break down necessary and vital tissue, as they only react with certain harmful proteins in the body.\u003c\/p\u003e\n\u003ch5\u003eWhat are \"Systemic Enzymes\"?\u003c\/h5\u003e\n\u003cp\u003eWhen enzymes are introduced into the bloodstream, they work “systemically”, or throughout the entire body. Taking enzymes on an empty stomach allows them to work systemically since they will bypass the upper digestive process and enter the bloodstream through the intestine. Systemic enzymes are similar to digestive enzymes, though certain enzymes are better designed for systemic activity as opposed to digestion due to the materials they react with, such as Serrapeptase and Nattokinase. These two enzymes are very efficient with the breakdown of a particular substance known as Fibrin.\u003c\/p\u003e\n\u003ch5\u003eWhat is Fibrin?\u003c\/h5\u003e\n\u003cp\u003eFibrin is a protein substance naturally formed in the human body that plays a significant role in our health and general well-being. Fibrin is responsible for scar tissue formation, and is produced as a reaction to injury. Our bodies naturally maintain healthy fibrin levels with enzymes (principally plasmin) whose role is to attack and break down any excessive fibrin. As fibrin builds up in the body, it can cause many unhealthy conditions.\u003c\/p\u003e\n\u003ch5\u003eWhy Neprinol?\u003c\/h5\u003e\n\u003cp\u003eAs we age, our natural enzyme production decreases while the need for these enzymes is of increasing importance. Supplementing these valuable enzymes can combat enzyme deficiencies that can lead to a wide variety of health concerns. Healthy levels of these enzymes can assist the body in maintaining a healthy immune system, healthy joints, proper circulation and an overall balanced reaction to injury.\u003c\/p\u003e\n\u003ch5\u003eHow Does Neprinol Work?\u003c\/h5\u003e\n\u003cp\u003eBy supplementing and replenishing the body's diminishing enzymes, Neprinol provides one of our most essential and basic biochemical needs. It supplements the body's natural fibrinolytic enzyme levels thereby helping to maintain healthy fibrin levels: an underlying causative agent for many unhealthy conditions in the body.*\u003c\/p\u003e\n\u003ch5\u003eIs Neprinol Enteric Coated?\u003c\/h5\u003e\n\u003cp\u003eEnteric coatings are designed to protect enzymes and other supplements from stomach acid. Plastic-like chemicals known as phthalates are often used in this coating process. Phthalates are actually banned in children's toys in Europe and Mexico, so why would we ever include these in our formulas? Arthur Andrew Medical has instead developed an all-natural, chemical-free Acid Armor capsule. These capsules are comprised of an extra-thick layer of cellulose (vegetable capsules) with a micro threaded locking mechanism to prevent leaking. Acid Armor capsules have been designed to delay the release of the capsule's contents for up to an hour without the use of potentially harmful chemicals.\u003c\/p\u003e\n\u003ch5\u003eIs Neprinol Safe?\u003c\/h5\u003e\n\u003cp\u003eNo serious or adverse side effects have been reported from taking systemic enzymes such as Neprinol*. Clinical studies have shown that even extremely large doses of these enzymes are not toxic. If you are taking blood-thinning medication, you should consult with your physician before taking Neprinol.\u003c\/p\u003e\n\u003cp\u003e*These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.\u003c\/p\u003e\n\u003cp\u003eNeprinol contains Pharmaceutical-grade ingredients. The product is provided exclusively through licensed health-care practitioners and supplementation outlet stores. Neprinol is 100% natural and contains no animal derivatives.\u003c\/p\u003e\n\u003cdiv class=\"sixteen columns\"\u003e\u003c\/div\u003e\n\u003chr class=\"pagedivider\"\u003e\n\u003cbr\u003e\n\u003ch6\u003eReferences:\u003c\/h6\u003e\n\u003col\u003e\n\u003cli\u003eMeletis CD, Barker JE. Therapeutic enzymes: using the body's helpers as healers. Alt Comp Ther. 2005;74-77.\u003c\/li\u003e\n\u003cli\u003eMeade TW. Fibrinogen and cardiovascular disease. J Clin Pathol. 1997;50:13-15.\u003c\/li\u003e\n\u003cli\u003eMilner M, Makise K. Natto and its Active Ingredient Nattokinase: a potent and safe thrombolytic agent. Alt Comp Therap. 2002;8(3):157-164.\u003c\/li\u003e\n\u003cli\u003eKoenig W. Fibrin(ogen) in cardiovascular disease: an update. Thromb Haemost. 2003;89:601-609.\u003c\/li\u003e\n\u003cli\u003eLefevre M, Kris-Etherton PM, Zhao G, Tracy RP. Dietary fatty acids, hemostasis, and cardiovascular disease risk. J Am Diet Assoc. 2004;104:410-419.\u003c\/li\u003e\n\u003cli\u003eKannel WB. Overview of hemostatic factors involved in atherosclerotic cardiovascular disease.Lipids. 2005;40:1215-1220.\u003c\/li\u003e\n\u003cli\u003eEidelman RS, Hennekens CH. Fibrinogen: a predictor of stroke and marker of atherosclerosis.Eur Heart J. 2003;24:499-500.\u003c\/li\u003e\n\u003cli\u003eNesheim M. Myocardial infarction and the balance between fibrin deposition and removal. Ital Heart J. 2001;2:641-645.\u003c\/li\u003e\n\u003cli\u003eFujita M, Hong K, Ito Y, et al. Thrombolytic effect of nattokinase on a chemically induced thrombosis model in rat. Biol Pharm Bull. 1995;18:1387-1391.\u003c\/li\u003e\n\u003cli\u003eSumi H, Hamada H, Tsushima H, Mihara H, Muraki H. A novel fibrinolytic enzyme (nattokinase) in the vegetable cheese Natto; a typical and popular soybean food in the Japanese diet.Experientia. 1987;43:1110-1111.\u003c\/li\u003e\n\u003cli\u003ePais E, Alexy T, Holsworth RE Jr, Meise HJ. Effects of nattokinase, a pro-fibrinolytic enzyme, on red blood cell aggregation and whole blood viscosity. Clin Hemorheol Microcirc. 2006;35:139-142.\u003c\/li\u003e\n\u003cli\u003eSumi H, Hamada H, Nakanishi K, Hiratani H. Enhancement of the fibrinolytic activity in plasma by oral administration of nattokinase. Acta Haematol. 1990;84:139-143.\u003c\/li\u003e\n\u003cli\u003eSuzuki Y, Kondo K, Matsumoto Y, et al. Dietary supplementation of fermented soybean, natto, suppresses intimal thickening and modulates the lysis of mural thrombi after endothelial injury in rat femoral artery. Life Sci. 2003;73:1289-1298.\u003c\/li\u003e\n\u003cli\u003eHamsten A, de Faire U, Walldius G, et al. Plasminogen activator inhibitor in plasma: risk factor for recurrent myocardial infarction.Lancet. 1987;2:3-9.\u003c\/li\u003e\n\u003cli\u003eHsia C-H, Shen M-C, Lin J-S, et al. Nattokinase decreases plasma levels of fibrinogen, factor VII, and factor VIII in human subjects. Nutr Res. 2009;29:190-196.\u003c\/li\u003e\n\u003cli\u003eCesarone MR, Belcaro G, Nicolaides AN, et al. Prevention of venous thrombosis in long-haul flights with Flite Tabs: The LONFLIT-FLITE randomized, controlled trial. Angiology. 2003;54:531-539.\u003c\/li\u003e\n\u003cli\u003eMaurer HR. Bromelain: biochemistry, pharmacology and medical use. Cell Mol Life Sci.2001;58:1234-1245.\u003c\/li\u003e\n\u003cli\u003ePirotta F, de Giuli-Morghen C. Bromelain: antiinflammatory and serum fibrinolytic activity after oral administration in the rat. Drugs Exp Clin Res. 1978;4:1-20.\u003c\/li\u003e\n\u003cli\u003eAko H, Cheung AH, Matsuura PK. Isolation of a fibrinolysis enzyme activator from commercial bromelain. Arch Int Pharmacodyn Ther. 1981;254(1):157-167.\u003c\/li\u003e\n\u003cli\u003eMaurer HR, Eckert K, Grabowska E, Eschmann K. Use of bromelain proteases for inhibiting blood coagulation. Patent WO PCT\/EP 98\/04406. 2000.\u003c\/li\u003e\n\u003cli\u003eDe-Giuli M, Pirotta F. Bromelain, interaction with some protease inhibitor and rabbit specific antiserum. Drugs Exp Clin Res. 1978;4:21-23.\u003c\/li\u003e\n\u003cli\u003eSmyth RD, Brennan R, Martin GJ. Systemic biochemical changes following the oral administration of a proteolytic enzyme, bromelain. Arch Int Pharmacodyn. 1962;136:230-236.\u003c\/li\u003e\n\u003cli\u003eTaussig SJ. The mechanism of the physiological action of bromelain. Med Hypotheses. 1980;6(1):99-104.\u003c\/li\u003e\n\u003cli\u003eFelton GE. Fibrinolytic and antithrombotic action of bromelain may eliminate thrombosis in heart patients. Med Hypotheses. 1980;6(1):1123-1133.\u003c\/li\u003e\n\u003cli\u003eSandhya KV, Devi SG, Mathew ST. Quantitation of serrapeptase in formulations by UV method in the microplate format. Curr Drug Deliv. 2008;5(4):303-305.\u003c\/li\u003e\n\u003cli\u003eMazzone A, Catalani M, Costanzo M, et al. Evaluation of Serratia peptidase in acute or chronic inflammation of otorhinolaryngology pathology: A multicentre, doubleblind, randomized trial versus placebo. J Int Med Res. 1990;18:379-388.\u003c\/li\u003e\n\u003cli\u003eSobel RA, Mitchell ME. Fibronectin in multiple sclerosis lesions. Am J Pathol.1989;135:161-168.\u003c\/li\u003e\n\u003cli\u003eGveric D, Hanemaaijer R, Newcombe J, van Lent NA, Sier CF, Cuzner ML. Plasminogen activators in multiple sclerosis lesions: implications for the inflammatory response and axonal damage. Brain.2001;124(Pt 10):1978-1988.\u003c\/li\u003e\n\u003cli\u003ePretorius E, Oberholzer HM. Ultrastructural changes of platelets and fibrin networks in human asthma: a qualitative case study. Blood Coagul Fibrinolysis. 2009;20(2):146-149.\u003c\/li\u003e\n\u003cli\u003eAkassoglou K, Adams RA, Bauer J, et al. Fibrin depletion decreases inflammation and delays the onset of demyelination in a tumor necrosis factor transgenic mouse model for multiple sclerosis. Proc Natl Acad Sci USA. 2004;101(17):6698-6703.\u003c\/li\u003e\n\u003cli\u003eBardos H, Molnar P, Csecsei G, Adany R. Fibrin deposition in primary and metastatic human brain tumours. Blood Coagul Fibrinolysis. 1996;7:536-548.\u003c\/li\u003e\n\u003c\/ol\u003e","brand":"Arthur Andrew Medical","offers":[{"title":"90 Capsules","offer_id":554269345,"sku":"nepr-90","price":54.99,"currency_code":"USD","in_stock":true},{"title":"150 Capsules","offer_id":554269341,"sku":"nepr-150","price":84.99,"currency_code":"USD","in_stock":true},{"title":"300 Capsules","offer_id":554269337,"sku":"nepr-300","price":144.99,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0368\/5697\/products\/Neprinol.png?v=1602090302","url":"https:\/\/enzymus.myshopify.com\/products\/neprinol-afd","provider":"Enzymus Medical","version":"1.0","type":"link"}